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MABC1750-25UG Anti-Placental Lactogen Antibody, clone mAb-12

Anti-Placental Lactogen, clone mAb-12, Cat. No. MABC1750, is a mouse monoclonal antibody that detects human placental lactogen and is tested for use in Immunohistochemistry (Paraffin), and Western Blotting.

MABC1750-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABC1750-25UG
      DescriptionAnti-Placental Lactogen Antibody, clone mAb-12
      Alternate Names
      • Chorionic somatomammotropin hormone 1
      • Choriomammotropin Lactogen
      • PL
      Background InformationChorionic somatomammotropin hormone 1 (UniProt: P0DML2; also known as Choriomammotropin, Lactogen, Placental lactogen, hPL) is encoded by the CSH1 gene (Gene ID: 1442) in human. Placental lactogen is a member of the somatotropin/prolactin family that is produced by the syncytiotrophoblast of the placenta and its levels are reported to be high in the maternal circulation during mid to late pregnancy. It is produced only during pregnancy and is involved in stimulating lactation, fetal growth, and metabolism. It does not interact with significantly with growth hormone receptor, but only binds and activates prolactin receptor through zinc-induced dimerization. hPL is synthesized with a signal peptide (aa 1-26), which is subsequently cleaved off to produce the mature form. It is first detected in maternal circulation at six weeks of gestation and its levels progressively rise until term. However, only a small amount is reported to cross placenta into the fetal circulation. Although expression of hPL and higher levels of mRNA have been reported in breast cancers, it has been argued and supported by some data, which suggests that a mechanism might exist that inhibits translation of CSH mRNA in breast cancer. (Ref.: Tuttle, TR., et al. (2014). PLoS One. 9(1); e87325l Idelman, G., et al. (2011). Expert Rev. Endocrinol. Metab. 6(3); 411-422).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-Placental Lactogen, clone mAb-12, Cat. No. MABC1750, is a mouse monoclonal antibody that detects human placental lactogen and is tested for use in Immunohistochemistry (Paraffin), and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:200 dilution from a representative lot detected Placental Lactogen in human placenta tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A representative lot detected Placental Lactogen in Immunohistochemistry applications (Tuttle, T.R., et. al. (2014). PLos One. 9(1):e87325).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenLinear Peptide corresponding to 11 amino acids from the C-terminal half of human Placental Lactogen.
      EpitopeC-terminal half
      ClonemAb-12
      Concentration1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone mAB-12 is a mouse monoclonal antibody that detects human Placental Lactogen. It targets an epitope within 11 amino acid from the C-terminal half.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CSH1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~21 kDa observed; 25.02 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Human placenta tissue lysates.

      Western Blotting Analysis: 4 µg/mL of this antibody detected Placental Lactogen in Human placenta tissue lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at +2°C to +8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC1750-25UG 04061842378159

      Documentation

      Anti-Placental Lactogen Antibody, clone mAb-12 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Placental Lactogen Antibody, clone mAb-12 Certificates of Analysis

      TitleLot Number
      Anti-Placental Lactogen, clone mAb-12 - Q3484322 Q3484322

      References

      Reference overviewPub Med ID
      Placental lactogen is expressed but is not translated into protein in breast cancer.
      Tuttle TR, Hugo ER, Tong WS, Ben-Jonathan N.
      PLoS One  9(1)  e87325  2014

      Show Abstract       		24475273 24475273