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MABN1867-25UL Anti-PRRT1 Antibody, clone L102/45

Anti-PRRT1, clone L102/45, Cat. No. MABN1867, is a highly specific mouse monoclonal antibody that targets Proline-rich transmembrane protein 1 and has been tested for use in Western Blotting.

MABN1867-25UL
25 µL  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABN1867-25UL
      DescriptionAnti-PRRT1 Antibody, clone L102/45
      Alternate Names
      • Proline-rich transmembrane protein 1
      • Dispanin subfamily D member 1
      • DSPD1
      • Synapse differentiation-induced protein 4
      Background InformationProline-rich transmembrane protein 1 (UniProt: Q6MG82; also known as Dispanin subfamily D member 1, DSPD1, Synapse differentiation-induced protein 4) is encoded by the Prrt1 (also known as Ng5) gene (gene ID: 406167) in rat. DSPD1 is a highly conserved, multi-pass membrane protein of the CD225/Dispanin family that is expressed in the brain and is detected in excitatory synapses. It contains two transmembrane helices, with both the N and C-termini oriented towards the outside of the cell. It plays an important role during synapse development in regulating AMPA receptor (AMPAR) and PSD-95 content at excitatory synapses. It is a component of the outer core of AMPAR complex. AMPAR complex consists of an inner core that is made of four pore-forming GluA/GRIA proteins and four major auxiliary subunits arranged in two-fold symmetry. The inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PRRT1, clone L102/45, Cat. No. MABN1867, is a highly specific mouse monoclonal antibody that targets Proline-rich transmembrane protein 1 and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to the first 66 amino acids from the N-terminal region of rat Proline-rich transmembrane protein 1 (PRRT1).
      EpitopeN-terminus
      CloneL102/45
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone L102/45 is a mouse monoclonal antibody that detects Proline-rich transmembrane protein 1 (PRRT1). It targets an epitope within 66 amino acids from the N-terminal, extracellular domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Prrt1
      • Ng5
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~40 kDa observed; 31.39 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human hippocampus tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected PRRT1 in human hippocampus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1867-25UL 04061841031789