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MABF2071-25UG Anti-PLVAP Antibody, clone MECA-32

Anti-PLVAP, clone MECA-32, Cat. No. MABF2071, is a rat monoclonal antibody tht detects Plasmalemma vesicle-associated protein (PV_1) and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.

Anti-PLVAP Antibody, clone MECA-32 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Plvap, Pv1 UniProt Number: Q91VC4
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MABF2071-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MIH(P), IP, WBRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF2071-25UG
      DescriptionAnti-PLVAP Antibody, clone MECA-32
      Alternate Names
      • Plasmalemma vesicle-associated protein
      • MECA-32 antigen
      • Plasmalemma vesicle protein 1
      • PV-1
      Background InformationPlasmalemma vesicle-associated protein (UniProt: Q91VC4; also known as MECA-32 antigen, Plasmalemma vesicle protein 1, PV-1) is encoded by the Plvap (also known as Pv1) gene (Gene ID: 84094) in murine species. MECA-32 is a single-pass type II membrane protein that is involved in the formation of stomatal and fenestral diaphragms of caveolae and may also function in microvascular permeability. It is expressed in lung, kidney, spleen, heart, muscle, eye, pancreas, thyroid, thymus, submaxillary gland, prostate, epididymis, uterus, and liver. MECA-32 contains three coiled coil regions (aa 140-160; 189-224; and 281-383). It has a short cytoplasmic domain (aa 1-26), a transmembrane domain (aa 27-47), and a long extracellular domain (aa 48-438). In mouse embryo it is expressed at 7 days post coitum (dpc). Its expression in the brain its expression is negatively correlated with the differentiation of the vasculature to form the blood brain barrier. Between 12 to 16 dpc higher expression is observed in endothelial cell surfaces of blood vessels in the brain. (Ref.: Hallmann, R., et al. (1995). Dev. Dynamics. 202; 525-332).
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PLVAP, clone MECA-32, Cat. No. MABF2071, is a rat monoclonal antibody tht detects Plasmalemma vesicle-associated protein (PV_1) and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A representative lot detected PLVAP in Immunohistochemistry applications (Tanneau, G.M., et. al. (1999). J Histochem Cytochem. 47(12):1581-92; Hallmann, R., et. al. (1995). Dev Dyn. 202(4):325-32).

      Immunohistochemistry Analysis: A representative lot detected PLVAP in Immunohistochemistry applications (Kopp, H.G., et. al. (2005). Blood. 106(2):505-13).

      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PLVAP in mouse liver tissue.

      Immunoprecipitation Analysis: A representative lot detected PLVAP in Immunoprecipitation applications (Hallmann, R., et. al. (1995). Dev Dyn. 202(4):325-32).

      Western Blotting Analysis: A representative lot detected PLVAP in Western Blotting applications (Hallmann, R., et. al. (1995). Dev Dyn. 202(4):325-32).
      Biological Information
      ImmunogenMouse lymph node stromal cells.
      CloneMECA-32
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone MECA-32 is a rat monoclonal antibody that detects Plasmalemma vesicle-associated protein (PLVAP) in murine species.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Plvap
      • Pv1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight50- 55 kDa observed; 49.93 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse kidney tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected PLVAP in mouse kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2071-25UG 04054839431821