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ABN465 Anti-PICALM Antibody

Anti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.

Anti-PICALM Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PICALM UniProt Number: Q13492
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ABN465
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN465
      DescriptionAnti-PICALM Antibody
      Alternate Names
      • Phosphatidylinositol-binding clathrin assembly protein
      • LAP
      • CALM
      • CLTH
      • Clathrin assembly lymphoid myeloid leukemia protein
      Background InformationPhosphatidylinositol-binding clathrin assembly protein (PICALM), also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area as a component of the coated pit internalization machinery. PICALM fusion proteins have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia, and chromosomal aberrations are found in diffuse histiocytic lymphomas. PICALM is also expressed in neuronal synapses where it facilitates the endocytosis of VAMP2. PICALM variants are associated with Alzheimer's disease and are thought to be involved in the endocytosis and recycling of the amyloid protein precursor (APP).
      References
      Product Information
      FormatAffinity Purified
      Control
      • EL4 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PICALM.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody can recognize all isoforms of PICALM.
      Species Reactivity
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • PICALM
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~62 kDa and ~71 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~60 kDa and ~71 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in EL4 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected PICALM in 15 µg of EL4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN465 04053252909993