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ABD132 Anti-PHOX2B Antibody

Detect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.

Anti-PHOX2B Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Pluripotent & Early Differentiation Gene Symbol: PHOX2B UniProt Number: Q99453
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ABD132
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD132
      DescriptionAnti-PHOX2B Antibody
      Alternate Names
      • Paired-like homeobox 2B
      • Paired mesoderm homeobox protein 2B
      • PMX2B
      • Neuroblastoma Phox
      • NBLST2
      • NBPhox
      • PHOX2B homeodomain protein
      Background InformationPaired mesoderm homeobox protein 2B (PHOX2B), also known as Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, and Paired-like homeobox 2B is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2B is expressed in neuroblastoma, brain and adrenal gland. PHOX2B defects can cause congenital central hypoventilation syndrome (CCHS) and susceptibility to neuroblastoma type 2 (NBLST2). PHOX2 regulation may have therapeutic potential in aging or degenerative noradrenergic neuron disorders.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PHOX2B.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • PHOX2B
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~22 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected PHOX2B in 15 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABD132 04053252910050