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MABN281 Anti-Numb Antibody, clone 6G10.1

Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.

Anti-Numb Antibody, clone 6G10.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: NUMB UniProt Number: P49757
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MABN281
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN281
      DescriptionAnti-Numb Antibody, clone 6G10.1
      Alternate Names
      • Protein numb homolog
      • h-Numb
      • S171
      Background InformationNumb plays a key role in neurogenesis and in cell fate decisions. It maintains self-renewal properties in neural progenitor cells, which are also called radial glial cells (RGCs). It functions through inhibition of Notch signaling. Additionally, it is suggested to mediate local repair in brain ventricular wall damage.
      References
      Product Information
      FormatPurified
      Control
      • A431 cell lysate
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Numb in HeLa and A431 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Numb isoforms 1 and 2.
      Clone6G10.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes Numb isoforms 1 and 2.
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • NUMB
      UniProt Number
      UniProt SummaryFUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

      SUBUNIT STRUCTURE: Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.

      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
      Molecular Weight~70 kDa observed. Uniprot describes four isoforms at ~71 kDa (isoform 1), ~66 kDa (isoform 2), ~69 kDa (isoform 3), and ~65 kDa (isoform 4).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in A431 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Numb in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN281 04053252437359

      Documentation

      Anti-Numb Antibody, clone 6G10.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Numb Antibody, clone 6G10.1 Certificates of Analysis

      TitleLot Number
      Anti-Numb, clone 6G10.1 - 2388374 2388374
      Anti-Numb, clone 6G10.1 - 2287226 2287226
      Anti-Numb, clone 6G10.1 - 2329827 2329827
      Anti-Numb, clone 6G10.1 - 3310673 3310673
      Anti-Numb, clone 6G10.1 - Q1972617 Q1972617
      Anti-Numb, clone 6G10.1 -2514268 2514268
      Anti-Numb, clone 6G10.1 -2807705 2807705
      Anti-Numb, clone 6G10.1 Monoclonal Antibody 3046701
      Anti-Numb, clone 6G10.1 Monoclonal Antibody 2898928

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies