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AB10239 Anti-NQO-1 Antibody

Anti-NQO-1 Antibody detects level of NQO-1 & has been published & validated for use in WB.

Research Category: Metabolism Research Sub-Category: Toxicology & Drug Resistance UniProt Number: P15559
AB10239
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, PmWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10239
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NQO-1 Antibody
      Alternate Names
      • NAD(P)H dehydrogenase
      • quinone 1
      • Menadione reductase
      • NAD(P)H menadione oxidoreductase 1, dioxin-inducible
      • NAD(P)H:Quinone acceptor oxidoreductase type 1
      • NAD(P)H:menadione oxidoreductase 1
      • NAD(P)H:quinone oxidoreductase 1
      • NAD(P)H:quinone oxireductase
      • Phylloquinone reductase
      • Quinone reductase 1
      • diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
      • dioxin-inducible 1
      Background InformationNAD(P)H dehydrogenase, quinone 1, also known as NQO-1, is a human gene which encodes a cytoplasmic 2-electron reductase. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD).
      References
      Product Information
      FormatSerum
      PresentationRaw rabbit serum with 0.05% sodium azide.
      Applications
      ApplicationAnti-NQO-1 Antibody detects level of NQO-1 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: A 1:5000 dilution of this lot detected baculovirus expressed recombinant NQO-1 protein.
      Biological Information
      ImmunogenRecombinant NQO-1
      EpitopeG115 – K274
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Primate
      Species Reactivity NoteHuman. Expected to react with mouse, rat and primate based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
      UniProt Number
      UniProt SummaryFunction: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
      Catalytic activity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
      Cofactor: FAD.
      Enzyme regulation: Inhibited by dicoumarol.
      Subunit structure: Homodimer.
      Subcellular location: Cytoplasm.
      Induction By: dioxin.
      Polymorphism: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.
      Miscellaneous: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
      Sequence similarities: Belongs to the NAD(P)H dehydrogenase (quinone) family.
      Molecular Weight31 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on baculovirus expressed recombinant NQO-1.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10239 04053252469893

      Documentation