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MABN770 Anti-Melanopsin Antibody, clone 1F8.1

This Anti-Melanopsin Antibody, clone 1F8.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Melanopsin .

Anti-Melanopsin Antibody, clone 1F8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: OPN4, MOP UniProt Number: Q9UHM6
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MABN770
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN770
      DescriptionAnti-Melanopsin Antibody, clone 1F8.1
      Alternate Names
      • Melanopsin
      • Opsin-4
      Background InformationMelanopsin (UniProt Q9UHM6; also known as Opsin-4) is encoded by the OPN4 (also known as MOP) gene (Gene ID 94233) in human. Opsins belong to the superfamily of G protein-coupled receptors (GPCRs). Melanopsin is a blue light-sensitive opsin protein that is capable of rendering cells intrinsically light responsive. Melanopsin expression defines a population of retinal ganglion cells that are intrinsically photosensitive (ipRGCs). Melanopsin allows mammals to measure irradiance for centrally mediated responses such as circadian entrainment. In addition, the information generated by melanopsin is used by the visual system as a signal for light adaptation. Using melanopsin-dependent phototransduction mechanism coupled with extrinsic signals originating with rods and cones, ipRGCs can encode light levels over many decimal orders, allowing the visual system to adapt to a broad range of light intensity from starlight to broad daylight.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aλ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Melanopsin Antibody, clone 1F8.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Melanopsin .
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Melanopsin in human retina tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Melanopsin C-terminal sequence
      EpitopeNear C-terminus
      Clone1F8.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1F8.1 is expected to react with both spliced isoforms of human melanopsin.
      IsotypeIgG2aλ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPN4
      • MOP
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~52 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human retinal pigment epithelia (RPE) ARPE-19 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Melanopsin in 10 µg of human retinal pigment epithelia (RPE) ARPE-19 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN770 04055977175431

      Documentation

      Anti-Melanopsin Antibody, clone 1F8.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Melanopsin Antibody, clone 1F8.1 Certificates of Analysis

      TitleLot Number
      Anti-Melanopsin, clone 1F8.1 - 3202189 3202189
      Anti-Melanopsin, clone 1F8.1 - 3336230 3336230
      Anti-Melanopsin, clone 1F8.1 - 3819910 3819910
      Anti-Melanopsin, clone 1F8.1 -Q2578148 Q2578148

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.