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ABE1404 Anti-MAFA Antibody

This Anti-MAFA Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of MAFA.

Anti-MAFA Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: MAFA UniProt Number: Q8NHW3
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ABE1404
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1404
      DescriptionAnti-MAFA Antibody
      Alternate Names
      • Transcription factor MafA
      • Pancreatic beta-cell-specific transcriptional activator
      • Transcription factor RIPE3b1
      • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
      Background InformationMAFA is a tissue specific transcription factor found in the nuclei of pancreas islet beta cells. MAFA specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. MAFA also cooperates synergistically with NEUROD1 and PDX1 in enhancing additional gene expression during development as well. Phosphorylation by GSK3 increases MAFA transcriptional activity and is required for its oncogenic activity. MAFA can be either an oncogene or act as a tumor suppressor, depending on the cell context.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-MAFA Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of MAFA.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot was reported to detect MAFA in HeLa, 293T/17, Capan-2, SAOS-2, SH-SY5Y, and Skin 3, 44 cells.
      Biological Information
      ImmunogenMixture of three linear peptides corresponding to amino acids 1-150 of human MAFA.
      EpitopeRegion near the N-terminus of MAFA
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityRecognizes MAFA
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MAFA
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~ 35 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in a HEK293T cell lysate.

      Western Blotting Analysis: A 1 µg/mL dilution of this antibody detected MAFA in a 293T cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1404 04055977051988