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MABS1204 Anti-M-Ras Antibody, clone 11F7.1

Anti-M-Ras Antibody, clone 11F7.1 is an antibody against M-Ras for use in Western Blotting.

Anti-M-Ras Antibody, clone 11F7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: MRAS, RRAS3 UniProt Number: O14807
MABS1204
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1204
      DescriptionAnti-M-Ras Antibody, clone 11F7.1
      Alternate Names
      • Ras-related protein M-Ras
      • Ras-related protein R-Ras3
      Background InformationRas-related protein M-Ras (UniProt O14807; also known as Ras-related protein R-Ras3) is encoded by the MRAS (also known as RRAS3) gene (Gene ID 22808) in human. Originally characterized as a protein that is involved in actin filament reorganization-induced microspikes formation, M-Ras is a Ras superfamily member predominantly expressed in brain and less abundantly in skeletal muscle and heart. M-Ras and Ras share several common effector molecules, and M-Ras is reported to mediate NGF-stimulated ERK pathway signaling by activating B-Raf in PC12 cells. Unlike Ras, however, NGF-stimulation of PC12 cells results in a sustained activation of M-Ras, while only a trarnsient activation is observed with Ras. M-Ras is initially produced in a 208-amino acid proform, the 3 amino acids at the C-terminal end (a.a. 206-208) is removed posttranslationally to yield the mature protein.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-M-Ras Antibody, clone 11F7.1 is an antibody against M-Ras for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant internal fragment from the C-terminal half of human M-Ras.
      EpitopeInternal (C-terminal half).
      Clone11F7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms reported by UniProt (O14807).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MRAS
      • RRAS3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~24 kDa observed. 23.52 kDa (isoform 1) and 15.22 kDa (isoform 2) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SHSY-5Y cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected M-Ras in 10 µg of SHSY-5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1204 04055977332193