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ABS442 Anti-LZTR2 Antibody

Anti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC.

Anti-LZTR2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Metabolic Hormones & Receptors Gene Symbol: SEC16B UniProt Number: Q96JE7
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ABS442
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS442
      DescriptionAnti-LZTR2 Antibody
      Alternate Names
      • Leucine zipper-like transcription regulator 2
      • SEC16B
      • RGPR
      • RGPR-p117
      • KIAA1928
      • LZTR2
      • SEC16S
      • Regucalcin gene promoter region-related protein p117
      • Protein transport protein Sec16B
      • SEC16 homolog B
      Background InformationLeucine zipper-like transcription regulator 2 (LZTR2), also known as RGPR-p117, is a member of the SEC16 family and BTB-kelch superfamily. LZTR2 is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. Initially, it was described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is localized in the cytoplasm but is thought to translocate to the nucleus following a hormonal stimulation and mediated by protein kinase C signaling. Recent studies has suggested that there is a strong correlation between LZTR2 and obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations. This evidence implies that LZTR2 may play an important role in metabolism and obesity risk.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse kidney tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 5 µg/mL from a representative lot detected LZTR2 in mouse kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LZTR2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SEC16B
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~92 kDa and ~140 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~59 kDa, ~71 kDa, and ~117 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse kidney tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected LZTR2 in 15 µg of mouse kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS442 04053252905605