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MABS26 Anti-LDLR Antibody, clone C7

This Anti-LDLR Antibody, clone C7 is validated for use in WB for the detection of LDLR.

Anti-LDLR Antibody, clone C7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Lipid Metabolism & Weight Regulation Gene Symbol: LDLR, LDLCQ2, FH, FHC UniProt Number: P01131
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MABS26
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, BWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS26
      DescriptionAnti-LDLR Antibody, clone C7
      Alternate Names
      • low density lipoprotein receptor
      • LDL receptor
      Background InformationLow-Density Lipoprotein (LDL) Receptor is a mosaic protein that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). Mutations in LDLR are associated with familial hypercholesterolemia which is characterized by high levels of LDL in the blood.
      References
      Product Information
      FormatPurified
      Control
      • ARPE-19 cell lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-LDLR Antibody, clone C7 is validated for use in WB for the detection of LDLR.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPartially purified bovine adrenal LDL receptor
      CloneC7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes LDLR.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Bovine
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with bovine based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq].
      Gene Symbol
      • LDLR
      • LDLCQ2
      • FH
      • FHC
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01130 # Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.

      SIZE: 860 amino acids; 95376 Da

      SUBUNIT: Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      PTM: N- and O-glycosylated.

      DISEASE: SwissProt: P01130 # Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).

      SIMILARITY: SwissProt: P01130 ## Belongs to the LDLR family. & Contains 3 EGF-like domains. & Contains 7 LDL-receptor class A domains. & Contains 6 LDL-receptor class B repeats.
      Molecular Weight 160 kDa Observed The translation of LDLR mRNA yields a 120 kDa protein that is post-translationally modified in the Golgi apparatus into the mature, 160 kDa LDLR. (Tolleshaug, H., et al. (1982). Cell 30:715–724.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in ARPE-19 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected LDLR on 10 µg of ARPE-19 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS26 04053252629068

      Documentation

      Anti-LDLR Antibody, clone C7 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LDLR Antibody, clone C7 Certificates of Analysis

      TitleLot Number
      Anti-LDLR, clone C7 - 2128265 2128265
      Anti-LDLR, clone C7 - 2360599 2360599
      Anti-LDLR, clone C7 - 2370196 2370196
      Anti-LDLR, clone C7 - 1962624 1962624
      Anti-LDLR, clone C7 - 2038646 2038646
      Anti-LDLR, clone C7 - 2271213 2271213
      Anti-LDLR, clone C7 - 2302235 2302235
      Anti-LDLR, clone C7 - 2489988 2489988
      Anti-LDLR, clone C7 - 3244037 3244037
      Anti-LDLR, clone C7 - 3310143 3310143
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