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MABC971 Anti-Kallikrein-13/KLK13 Antibody, clone 33.1

This Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 is validated for use in Immunohistochemistry and ELISA for the detection of Kallikrein-13/KLK13.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Tumor Markers Gene Symbol: KLK13, KLKL4 UniProt Number: Q9UKR3
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MABC971
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC971
      DescriptionAnti-Kallikrein-13/KLK13 Antibody, clone 33.1
      Alternate Names
      • Kallikrein-13
      • Kallikrein-like protein 4
      • KLK-L4
      Background InformationKallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). Kallikreins are also associated with carcinogenesis and some serve as a novel cancer and other disease biomarkers. Kallikrein-13/KLK13 is important in lung cancer by allowing lung adenocarcinoma spreading through promoting the expression of various adhesion molecules and it in assisting in extracellular matrix protein degradation necessary for movement. Kallikrein-13/KLK13 also plays a role in salivary tumors and ovarian cancer as well as other cancers in a similar fashion. In both normal and cancerous tissues, Kallikrein-13/KLK13 is secreted into the ECM and expressed in many tissues in both the embryo and adult.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1k in 0.1 M Sodium Bicarbonate buffer pH8.2 without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 is validated for use in Immunohistochemistry and ELISA for the detection of Kallikrein-13/KLK13.
      Key Applications
      • Immunohistochemistry
      • ELISA
      Application NotesImmunohistochemistry Analysis: A representative lot of this antibody detected Kallikrein-13/KLK13 in Normal ovarian surface epithelium and epithelial ovarian cancer tissues (White et al., (2009) British Journal of Cancer. 101:1107-1113).

      ELISA: A representative lot of this antibody detected various Kallikrein-13/KLK13 concentrations of several human tissues (Kapadia et al., (2003) Clinical chemistry. 49(1):77–86).
      Biological Information
      ImmunogenRecombinant protein corresponding to Human Kallikrein-13/KLK13.
      Clone33.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK13
      • KLKL4
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight30 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human lung and human prostate tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Kallikrein-13/KLK13 in human prostate tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC971 04055977052985

      Documentation

      Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 Certificates of Analysis

      TitleLot Number
      Anti-Kallikrein-13/KLK13, clone 33.1 - Q2464790 Q2464790

      References

      Reference overviewPub Med ID
      KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
      White, N M A, et al.
      Br. J. Cancer, 101: 1107-13 (2009)  2009

      Show Abstract       		19707197 19707197
      Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay.
      Kapadia, Carl, et al.
      Clin. Chem., 49: 77-86 (2003)  2003

      Show Abstract       		12507963 12507963