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MAB1961H-I Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate

Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate is an antibody against Integrin αVβ5 for use in Flow Cytometry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ITGAV, MSK8, VNRA, VTNR, ITGB5 UniProt Number: P06756/P18084
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MAB1961H-I
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ch, HtFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberMAB1961H-I
      DescriptionAnti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate
      Alternate Names
      • Integrin alpha-V
      • CD51
      • Integrin alpha V
      • Vitronectin receptor subunit alpha
      • Integrin beta-5
      Background InformationIntegrin alpha-V (UniProt P06756; CD51, Integrin alpha V, Vitronectin receptor subunit alpha) and Integrin beta-5 (UniProt P18084) are encoded by the ITGAV (MSK8, VNRA, VTNR; Gene ID 3685) and the ITGB5 (Gene ID 3693) gene, respectively, in human. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and a beta subunit associated in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence present in the extracellular matrix components, such as fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Integrin alphaVbeta5 is the primary mechanotransducer that mediates lung myofibroblast contraction-induced latent TGF-beta1 activation. Increased alphaVbeta5 expression is reported to be associated with myofibroblast differentiation. Integrin alphaVbeta5 is shown to interact with Thy-1 in an RLD-dependent manner. Thy-1 expression prevents fibroblast contraction-induced latent TGF-beta1 activation and lung myofibroblast differentiation.
      References
      Product Information
      FormatPhycoerythrin
      PresentationPurified mouse monoclonal IgG1 antibody in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate is an antibody against Integrin αVβ5 for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesThe unconjugated antibody (Cat. No. MAB1961 & MAB1961Z) is shown to be suitable also for Flow cytometry, Functional blocking, Immunocytochemistry, Immunohistochemistry, and Immunoprecipitation applications.
      Biological Information
      ImmunogenHuman UCLA P3 lung carcinoma cells (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948).
      EpitopeExtracellular region.
      CloneP1F6
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone P1F6 recognizes αVβ5 without cross-reactivity toward αVβ3 (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948).
      IsotypeIgG1
      Species Reactivity
      • Human
      • Chicken
      • Hamster
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGAV
      • MSK8
      • VNRA
      • VTNR
      • ITGB5
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight112.7 kDa (alpha-V) and 86.34 kDa (beta-5) calculated. ~150 kDa (alpha-V) and 95 kDa (beta-5) reported (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948) due to glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in HT1080 cells.

      Flow Cytometry Analysis: 1.0 µg of this antibody detected Integrin αVβ5 in HT1080 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB1961H-I 04055977349603

      Documentation

      Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate Certificates of Analysis

      TitleLot Number
      Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3201463 3201463
      Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3517398 3517398
      Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3889539 3889539
      Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate -Q2676864 Q2676864