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04-1585 Anti-IL-18 Antibody, clone 12E7.1

Anti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC.

Anti-IL-18 Antibody, clone 12E7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL-18, IL18, IGIF, IL-18, IL1F4, IL-1g UniProt Number: Q14116
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04-1585
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIHC, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-1585
      DescriptionAnti-IL-18 Antibody, clone 12E7.1
      Alternate Names
      • interleukin 18 (interferon-gamma-inducing factor)
      • IL-1 gamma
      • IFN-gamma-inducing factor
      • iboctadekin
      • interleukin-18
      • Interleukin-1 gamma
      • Iboctadekin
      • Interferon gamma-inducing factor
      Background InformationInterleukin-18 (UniProt: Q14116; also known as IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma) is encoded by the IL18 (also known as IGIF, IL1F4) gene (Gene ID: 3606) in human. IL-18 is a pro-inflammatory cytokine that is shown to evoke both innate and acquired responses. It is synthesized with a propeptide (aa 1-36), which is subsequently cleaved off by caspases 1 and 4 to generate the active mature form. IL-18 is reported to be constitutively expressed in monocytes, macrophages, epithelial cells, osteoblasts, keratinocytes, and synovial fibroblasts. Its expression has also been reported in adrenal cortical cells. Mature IL-18 acts by binding to the IL-18 receptor a (IL-18a) to form a low affinity binary complex that recruits IL-18b to form a high affinity complex that leads to the activation of NF-kB and MAP kinase pathways. IL-18 can synergize with IL-12 to induce interferon-g synthesis from T-helper 1 and natural killer cells.
      References
      Product Information
      FormatPurified
      Control
      • Mouse splenocytes
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC.
      Key Applications
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in human tonsil tissue.

      Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in inflamed skin and normal human spleen tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IL-18.
      Clone12E7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
      Gene Symbol
      • IL-18
      • IL18
      • IGIF
      • IL-18
      • IL1F4
      • IL-1g
      UniProt Number
      UniProt SummaryFUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

      SUBCELLULAR LOCATION: Secreted.

      SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
      Molecular Weight~24 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse splenocytes.

      Flow Cytometry Analysis: 1 µg of this antibody detected IL-18 in mouse splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-1585 04053252629402

      Documentation

      Anti-IL-18 Antibody, clone 12E7.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-IL-18 Antibody, clone 12E7.1 Certificates of Analysis

      TitleLot Number
      Anti-IL-18, Clone 12E7.1 - 4068662 4068662
      Anti-IL-18, clone 12E7.1 - 2142592 2142592
      Anti-IL-18, clone 12E7.1 - 2430982 2430982
      Anti-IL-18, clone 12E7.1 - 2201511 2201511
      Anti-IL-18, clone 12E7.1 - 2283350 2283350
      Anti-IL-18, clone 12E7.1 - 2332581 2332581
      Anti-IL-18, clone 12E7.1 - 3234492 3234492
      Anti-IL-18, clone 12E7.1 - 3425584 3425584
      Anti-IL-18, clone 12E7.1 - 3750062 3750062
      Anti-IL-18, clone 12E7.1 - 3876260 3876260
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies