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MABC712 Anti-HAS2, clone 4E7 Antibody

Anti-HAS2, clone 4E7 Antibody is an antibody against HAS2 for use in western blotting, IHC, immunofluorescence & ELISA.

Anti-HAS2, clone 4E7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: HAS2 UniProt Number: Q92819
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MABC712
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IF, ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC712
      DescriptionAnti-HAS2, clone 4E7 Antibody
      Alternate Names
      • Hyaluronan synthase 2
      • Hyaluronate synthase 2
      • Hyaluronic acid synthase 2
      • HA synthase 2
      • HAS2
      Background InformationHyaluronan or hyaluronic acid, also known as Hyaluronan synthase 2 or Hyaluronate synthase 2 or Hyaluronic acid synthase 2 (HA synthase 2), and encoded by the gene name HAS2, is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal in PBS containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-HAS2, clone 4E7 Antibody is an antibody against HAS2 for use in western blotting, IHC, immunofluorescence & ELISA.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      • ELISA
      Application NotesImmunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected HAS2 in ovarian cancer tissue.

      Immunofluorescence Analysis: A 1;100-500 dilution from a representative lot detected HAS2 in HeLa cells.

      ELISA: A representative lot detected control antigen (100 ng) and antigen (10 ng, 50 ng, 100 ng) in ELISA (Direct).
      Biological Information
      ImmunogenPurified recombinant fragment of human HAS2 expressed in E. Coli
      Clone4E7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • HAS2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~55 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human plasma and Jurkat lysates.

      Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected HAS2 in human plasma and Jurkat lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC712 04053252957253

      Documentation

      Anti-HAS2, clone 4E7 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-HAS2, clone 4E7 Antibody Certificates of Analysis

      TitleLot Number
      Anti-HAS2, clone 4E7 - QVP1312042 QVP1312042
      Anti-HAS2, clone 4E7 -VP1408206 VP1408206
      Anti-HAS2, clone 4E7 -VP1504147 VP1504147
      Anti-HAS2, clone 4E7 -VP1510022 VP1510022
      Anti-HAS2, clone 4E7 -VP1601125 VP1601125
      Anti-HAS2, clone 4E7 -VP1607201 VP1607201
      Anti-HAS2, clone 4E7 Monoclonal Antibody VP1806152
      Anti-HAS2, clone 4E7 Monoclonal Antibody VP1710053
      Anti-HAS2, clone 4E7 Monoclonal Antibody VP1701065
      MABC712 - VP1912133 VP1912133

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies