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MABT418 Anti-GPVI Antibody, clone 8A2, Detection Antibody

Anti-GPVI Antibody, clone 8A2, Detection Antibody is an antibody against GPVI for use in western blotting & ELISA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: GP6 UniProt Number: Q9HCN6
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MABT418
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ELISARPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT418
      ReplacesMABT473
      DescriptionAnti-GPVI Antibody, clone 8A2, Detection Antibody
      Alternate Names
      • Platelet glycoprotein VI
      • GPVI
      • Glycoprotein 6
      Background InformationGlycoprotein VI (GPVI), or glycoprotein 6 (GP6), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GPVI is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GPVI is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GPVI is expressed in megakaryocytes and platelets. The signaling pathway of GPVI involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GPVI.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GPVI Antibody, clone 8A2, Detection Antibody is an antibody against GPVI for use in western blotting & ELISA.
      Key Applications
      • Western Blotting
      • ELISA
      Application NotesELISA Assay: A representative lot from an independent laboratory detected recombinant GPVI in a bead-based sandwich immunoassay (Bigalke, B., et al. (2011). Clin Chem. 57(6):898-904.). This antibody should be used in conjunction with Cat. No. MABT406, Anti-GPVI, clone 8E9, Capture Antibody, as an ELISA detection and capture antibody pair.
      Biological Information
      ImmunogenRecombinant protein corresponding to human GPVI.
      Clone8A2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GP6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~50 kDa observed. The calculated molecular weight of this protein is 37 kDa. However, a recombinant protein was observed at 50-55 kDa in Western Blotting.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in recombinant human GPVI glycoprotein.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected recombinant human GPVI glycoprotein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT418 04053252955464

      Documentation

      Anti-GPVI Antibody, clone 8A2, Detection Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GPVI Antibody, clone 8A2, Detection Antibody Certificates of Analysis

      TitleLot Number
      Anti-GPVI, clone 8A2, Detection Antibody - Q2383909 Q2383909
      Anti-GPVI, clone 8A2, Detection Antibody - 3249928 3249928

      References

      Reference overviewPub Med ID
      Sandwich immunoassay for soluble glycoprotein VI in patients with symptomatic coronary artery disease.
      Bigalke, Boris, et al.
      Clin. Chem., 57: 898-904 (2011)  2011

      Show Abstract       		21474641 21474641

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      ABS446 Anti-GPVI Antibody Show Pricing & Availability
      MABT406 Anti-GPVI Antibody, clone 8E9, Capture Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies