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ABS764 Anti-GPAT-1 Antibody

Anti-GPAT-1 Antibody is an antibody against GPAT-1 for use in western blotting, IHC & immunofluorescence.

Anti-GPAT-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: GPAM, GPAT1 UniProt Number: Q9HCL2
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ABS764
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS764
      ReplacesMABS402
      DescriptionAnti-GPAT-1 Antibody
      Alternate Names
      • Glycerol-3-phosphate acyltransferase 1, mitochondrial
      • GPAT-1
      Background InformationGlycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT-1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT-1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT-1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT-1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GPAT-1 Antibody is an antibody against GPAT-1 for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected GPAT-1 in rat brain tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPAT-1 in rat brain cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the C-terminus of human GPAT-1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • GPAM
      • GPAT1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~82 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected GPAT-1 in rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS764 04053252944062