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AB10532 Anti-GABA(A) receptor subunit gamma-2 Antibody

This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GEFSP3, CAE2, ECA2, GABRG2 UniProt Number: P18508
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AB10532
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10532
      DescriptionAnti-GABA(A) receptor subunit gamma-2 Antibody
      Alternate Names
      • gamma-aminobutyric acid (GABA) A receptor, gamma 2
      • gamma-aminobutyric acid A receptor, gamma 2
      • GABA(A) receptor subunit gamma-2
      Background InformationGABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
      References
      Product Information
      FormatSerum
      Control
      • PC12 cell lysate
      PresentationRabbit polyclonal serum containing 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2.
      HostRabbit
      SpecificityThis antibody recognizes GABA(A) receptor subunit gamma-2.
      Species Reactivity
      • Rat
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySubunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD].
      Gene Symbol
      • GEFSP3
      • CAE2
      • ECA2
      • GABRG2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

      SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

      SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

      PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).

      MISCELLANEOUS: This subunit carries the benzodiazepine binding site.

      SEQUENCE SIMLARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. (View classification)
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in PC12 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10532 04053252478802

      Documentation

      Anti-GABA(A) receptor subunit gamma-2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GABA(A) receptor subunit gamma-2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-GABA(A) receptor subunit -2550894 2550894
      Anti-GABA(A) receptor subunit gamma-2 - 2445044 2445044
      Anti-GABA(A) receptor subunit gamma-2 - 2039821 2039821
      Anti-GABA(A) receptor subunit gamma-2 - 3691429 3691429
      Anti-GABA(A) receptor subunit gamma-2 - 3808722 3808722
      Anti-GABA(A) receptor subunit gamma-2 - NG1881286 NG1881286
      Anti-GABA(A) receptor subunit gamma-2 - NRG1781528 NRG1781528

      Related Products & Applications

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      Catalogue Number Description  
      MABN263 Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies