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ABC347 Anti-Fn14 Antibody

Anti-Fn14 Antibody is a highly specific rabbit polyclonal antibody, that targets Fibroblast growth factor 14 & has been tested in western blotting, IHC & Immunofluorescence.

Anti-Fn14 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TNFRSF12A UniProt Number: Q9NP84
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ABC347
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC347
      DescriptionAnti-Fn14 Antibody
      Alternate Names
      • Fn14 Antibody
      • Fibroblast growth factor-inducible 14
      • TNFRSF12
      • TWEAK-R
      • FGF-inducible 14
      Background InformationFibroblast growth factor 14 (FN14) is a member of the TNF receptor superfamily. FN14 is a receptor for TNFSF12/TWEAK and promotes angiogenesis and the proliferation of endothelial cells. Experiments have shown that FN14 binds to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Additionally, FN14 is a weak inducer of apoptosis in some cell types and may modulate cellular adhesion to matrix proteins. FN14 is suggested to induce liver regeneration and is highly expressed in hepatocellular carcinomas. Furthermore, TWEAK induces liver progenitor cell proliferation, suggesting FN14 may play a role in hepatocyte growth control and liver neoplasia. FN14 is highly expressed in heart, placenta and kidney. Intermediate expression of FN14 has been recorded in lung, skeletal muscle and pancreas.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HepG2 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Fn14 Antibody is a highly specific rabbit polyclonal antibody, that targets Fibroblast growth factor 14 & has been tested in western blotting, IHC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected Fn14 in human liver tissue lysate.

      Immunofluorescence Analysis: 20 µg/mL from a representative lot detected Fn14 in human liver tissue.
      Biological Information
      ImmunogenKLH-conjugated Fc-tagged protein corresponding to human Fn14.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • TNFRSF12A
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~34 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~10 kDa and ~14 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 4 µg/mL of this antibody detected Fn14 in 15 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC347 04053252905100