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AB2277 Anti-FOXP1 Antibody

Anti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.

Anti-FOXP1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience, Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors, Transcription Factors Gene Symbol: FOXP1, QRF1, 12CC4, HSPC215, hFKH1B UniProt Number: Q9H334
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AB2277
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, B, Rhesus MacaqueWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2277
      DescriptionAnti-FOXP1 Antibody
      Alternate Names
      • fork head-related protein like B
      • forkhead box P1
      • glutamine-rich factor 1
      Background InformationForkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:300 dilution of AB2277 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.

      Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of FOXP1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Bovine
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Predicted to react with bovine, and rhesus monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
      Gene Symbol
      • FOXP1
      • QRF1
      • 12CC4
      • HSPC215
      • hFKH1B
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development (By similarity).

      SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity).

      SUBCELLULAR LOCATION: Nucleus Probable.

      DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression By similarity.

      INVOLVEMENT IN DISEASE: A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.

      SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.

      Contains 1 fork-head DNA-binding domain.

      SEQUENCE CAUTION: The sequence AAF36135.1 differs from that shown. Reason: Frameshift at positions 531 and 545.
      Molecular WeightFOXP1 has 4 isoforms observed at 75/73, 64 and 54 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected multiple isoforms of FOXP1 in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2277 04053252679117