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ABS1038 Anti-FMO5 Antibody

Anti-FMO5 Antibody is an antibody against FMO5 for use in Western Blotting, Immunohistochemistry.

Anti-FMO5 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: FMO5 UniProt Number: P49326
ABS1038
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABS1038
      DescriptionAnti-FMO5 Antibody
      Alternate Names
      • Dimethylaniline monooxygenase [N-oxide-forming] 5
      • Dimethylaniline oxidase 5
      • FMO 5
      • Hepatic flavin-containing monooxygenase 5
      Background InformationDimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8; UniProt P49326; also known as Dimethylaniline oxidase 5, FMO 5, Hepatic flavin-containing monooxygenase 5) is encoded by the FMO5 gene (Gene ID 2330) in human. FMO5 belongs to the family of Flavin-containing monooxygenase (FMO) genes that encode ER membrane flavin-containing monooxygenases. Humans possess five functional FMO genes (FMO1 to FMO5). FMO 1, 2 and 3 catalyze NADPH-dependent oxygenation of a wide array of foreign chemicals, while little is known about FMO 4 expression, substrates or activity. FMO 5 is highly expressed in the liver in human and murine species. FMO 5 is known to catalyze the N-oxygenation of short-chain aliphatic primary amines (e.g., N-octylamine) and the S-oxygenation of S-methyl-esonarimod, an active metabolite of the anti-rheumatic esonarimod. FMO 5 is also demonstrated to catalyze a Baeyer-Villiger oxidation reaction. However, FMO 5 exhibits little or no activity towards classic FMO substrates, such as methimazole, trimethylamine, and benzydamine. Fmo5 gene disruption in mice is reported to result in slowed metabolic aging via pleiotropic effects.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal antibody serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FMO5 Antibody is an antibody against FMO5 for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:500 dilutioin from a representative lot detected FMO5 in 10 µg of MCF-7 membrane extract.
      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO5 in rat and human liver tissue sections.
      Biological Information
      ImmunogenLinear peptide corresponding to a sequence from the N-terminal region of human FMO5.
      EpitopeN-terminal region.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpected to react with all three spliced isoforms of human FMO5 reported by UniProt (P49326).
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Mouse, Bovine, Guinea Pig based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FMO5
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~55/52/32 kDa observed. 60.22 kDa (isoform 1), 32.48 kDa (isoform 2), 52.48 kDa (isoform 3) calculated. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver tissue microsomal extract.

      Western Blotting Analysis: A 1:500 dilutioin of this antibody detected FMO5 in 10 µg of human liver tissue microsomal extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1038 04055977332278

      Documentation

      Anti-FMO5 Antibody Certificates of Analysis

      TitleLot Number
      Anti-FMO5 -Q2661662 Q2661662