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ABC116 Anti-EPS8, Antibody

This EPS8 antibody is validated for use in WB for the detection of the EPS8 protein.

Anti-EPS8, Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: EPS8 UniProt Number: Q12929
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ABC116
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC116
      DescriptionAnti-EPS8, Antibody
      Alternate Names
      • Epidermal growth factor receptor kinase substrate 8
      • EPS8
      Background InformationEPS8 (epidermal growth factor receptor kinase substrate 8), which was originally identified as a substrate for the kinase activity of EGFR, is a multifunctional protein that is known to play a role in spermatogenesis, the regulation of actin, and other cellular processes. EPS8 uses its SH3 domain to complex with Abi1 and SOS1, leading to Rac activation and subsequent actin cytoskeletal remodeling. In the same manner, it binds with RN-tre to inhibit the internalization of EGFR. EPS8 also works with Arp3 to modulate actin dynamics within the seminiferous epithelium at the apical ES and the BTB.
      References
      Product Information
      FormatAffinity Purified
      Control
      • NIH/3T3 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis EPS8 antibody is validated for use in WB for the detection of the EPS8 protein.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human EPS8.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      • Rat
      • Human
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Rat based on 100% sequence homology. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EPS8
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~97 kDa observed. A second isoform is known to exist at ~68 kDa. Uncharacterized bands may be observed at ~50 kDa and ~37 kDa in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

      Western Blot Analysis: 0.2 µg/mL of this antibody detected EPS8 in 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC116 04053252830808

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies