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MABT1490-50UL Anti-Cytokeratin-7 Antibody, clone 7D3

Anti-Cytokeratin-7, clone 7D3, Cat. No. MABT1490, is a rat monoclonal antibody that detects cytokeratin-7 and has been tested for use in Immunocytochemistry, Immunohistochemistry (Frozen), and Immunohistochemistry (Paraffin).

MABT1490-50UL
50 µL  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABT1490-50UL
      DescriptionAnti-Cytokeratin-7 Antibody, clone 7D3
      Alternate Names
      • Keratin
      • type II cytoskeletal 7
      • Cytokeratin-7
      • CK-7
      • Keratin-7
      • K7
      • Sarcolectin
      • Type-II keratin Kb7
      Background InformationKeratin, type II cytoskeletal 7 (UniProt: P08729; also known as Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7) is encoded by the KRT7 (also known as SCL) gene (Gene ID: 3855) in human. Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. CK-7 is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs. Its expression is reported in bronchial and mesothelial cells, but is absent in colon, ectocervix, and liver. It is also observed throughout the glandular cells in the junction between stomach and esophagus. However, it is absent in the esophagus. CK-7 is also typically expressed in tumor cells of mammary and extramammary Paget disease. CK-7 expression can be used to distinguish ovarian and gastrointestinal carcinomas, or transitional cell carcinomas and prostate cancer.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Cytokeratin-7, clone 7D3, Cat. No. MABT1490, is a rat monoclonal antibody that detects cytokeratin-7 and has been tested for use in Immunocytochemistry, Immunohistochemistry (Frozen), and Immunohistochemistry (Paraffin).
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:25 dilution from a representative lot detected Cytokeratin-7 in human breast cancer tissue sections.

      Immunocytochemistry Analysis: A representative lot detected Cytokeratin-7 in Immunocytochemistry applications (Zydek, M., et. al. (2014). Viruses. 6(3):1346-64; Tabata, T., et. al. (2015). J Virol. 89(9):5134-47; Maidji, E., et. al. (2002). Virology. 304(1):53-69).

      Immunohistochemistry Analysis: A representative lot detected Cytokeratin-7 in Immunohistochemistry applications (Zhou, Y., et. al. (2014). Am J Pathol. 184(12):3321-31; Schanz, A., et. al. (2014). Placenta. 35(12):1089-94; Genbacev, O., et. al. (2000). Am J Pathol. 157(4):1337-51).
      Biological Information
      ImmunogenWhole cytotrophoblast cells from 1st trimester human placenta.
      Epitopeextracellular domain
      Clone7D3
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone 7D3 is a rat monoclonal antibody that detects human Cytokeratin-7. It targets an epitope with in the extracellular domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KRT7
      • SCL
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight51.38 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human pancreatic cancer tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:25 dilution of this antibody detected Cytokeratin-7 in human pancreatic cancer tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT1490-50UL 04054839646782