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MABF1499 Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody

Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody is an antibody against CD117 for use in Flow Cytometry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Kit, SI UniProt Number: P05532
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MABF1499
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPE-Cy7Monoclonal Antibody
      Description
      Catalogue NumberMABF1499
      DescriptionAnti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody
      Alternate Names
      • Mast/stem cell growth factor receptor Kit (SCFR)
      • Proto-oncogene c-Kit
      • Tyrosine-protein kinase Kit
      • CD117
      • CD117 (c-Kit)
      Background InformationThe ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. Please choose the appropriate format for each application. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.
      Product Information
      FormatPE-Cy7
      PresentationPurified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody is an antibody against CD117 for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneACK2
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Kit
      • SI
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD117 (c-Kit) in one million C57Bl/6 bone marrow cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 μg
      Global Trade Item Number
      Catalogue Number GTIN
      MABF1499 04055977292176