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MABN1583 Anti-CALML5 Antibody, clone 3F6.1

Anti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-CALML5 Antibody, clone 3F6.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: CALML5, CLSP UniProt Number: Q9NZT1
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MABN1583
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1583
      DescriptionAnti-CALML5 Antibody, clone 3F6.1
      Alternate Names
      • Calmodulin-like protein 5
      • Calmodulin-like skin protein
      Background InformationCalmodulin-like protein 5 (UniProt Q9NZT1; also known as Calmodulin-like skin protein) is encoded by the CALML5 (also known as CLSP) gene (Gene ID 51806) in human. Epidermal differentiation and barrier function depend on many calcium-regulated proteins and enzymes. CALML5/CLSP is expressed in the stratum granulosum and lower layers of the stratum corneum of the skin, where it modulates the function of calcium-dependent proteins, such as transglutaminase 3. CALML5/CLSP level is upregulated in granular and spinal keratinocytes during the later stages of wound healing in human epidermis and eventually returns to basal level once the wound is closed and barrier function has been restored. In the hyperproliferative skin disorders psoriasis and atopic dermatitis (AD), the permeability barrier is disturbed, causing an increased CLSP built-up as a result of decresed CLSP degradation due to an altered calcium gradient.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CALML5 in human tonsil and skin tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human CALML5 lacking the first EF-hand motif.
      EpitopeOutside the first EF-hand motif.
      Clone3F6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 3F6.1 recognizes an epitope outside the first EF-hand motif.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CALML5
      • CLSP
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight15.89 kDa calculated. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of human CALML5 GST fusion protein.

      Western Blotting Analysis: 0.05 µg/mL of this antibody detected 0.05 µg of human CALML5 GST fusion protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1583 04055977335309