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AB5436P Anti-Brain and Muscle ARNT-Like 1 Antibody

Anti-Brain & Muscle ARNT-Like 1 Antibody is a Rabbit Polyclonal Antibody for detection of Brain & Muscle ARNT-Like 1 also known as BMAL1, MOP3/CYCLE & has been validated in ELISA & WB.

Anti-Brain and Muscle ARNT-Like 1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: ARNTL, BMAL1, MOP3, BMAL1c, TIC, PASD3, JAP3, MGC47515 UniProt Number: O00327
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AB5436P
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      DrELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5436P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Brain and Muscle ARNT-Like 1 Antibody
      Alternate Names
      • BMAL1
      • MOP3/CYCLE
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Brain & Muscle ARNT-Like 1 Antibody is a Rabbit Polyclonal Antibody for detection of Brain & Muscle ARNT-Like 1 also known as BMAL1, MOP3/CYCLE & has been validated in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.

      ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 22 amino acid peptide of drosophila BMAL1 (Darlington et al. 1998; Rutila et al. 1998; Bae et al. 1998). Gene accession # 3219728.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes drosophila BMAL1. The immunogen shows no significant sequence homology with mammalian Clock or Per proteins. Significant homology is seen with mammalian USF's (Upstream Stimulatory Factors 1 and 2) and human and mouse BMAL1 and ARNTs.

      SPECIES REACTIVITIES: The immunogen sequence has no homology with mammalian Clock or Per proteins. Reactivity with other species has not been confirmed.
      Species Reactivity
      • Drosophila
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
      Gene Symbol
      • ARNTL
      • BMAL1
      • MOP3
      • BMAL1c
      • TIC
      • PASD3
      • JAP3
      • MGC47515
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00327 # BMAL1-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).
      SIZE: 626 amino acids; 68762 Da
      SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.
      SUBCELLULAR LOCATION: Nucleus (By similarity).
      TISSUE SPECIFICITY: Highly expressed in the adult brain, skeletal muscle and heart.
      PTM: Phosphorylated upon dimerization with CLOCK (By similarity). & Sumoylated on Lys-259 upon dimerization with CLOCK (By similarity).
      SIMILARITY: SwissProt: O00327 ## Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 2 PAS (PER-ARNT-SIM) domains.
      MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5436P 04053252732850

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies