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MABE889 Anti-ADAR2 Antibody, clone 1.3.1

Anti-ADAR2 Antibody, clone 1.3.1 detects level of ADAR2 & has been published & validated for use in ADAR2.

Anti-ADAR2 Antibody, clone 1.3.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: ADARB1, ADAR2, DRADA2, RED1 UniProt Number: P78563
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MABE889
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE889
      DescriptionAnti-ADAR2 Antibody, clone 1.3.1
      Alternate Names
      • Double-stranded RNA-specific editase 1
      • RNA-editing deaminase 1
      • RNA-editing enzyme 1
      • dsRNA adenosine deaminase
      Background InformationDouble-stranded RNA-specific editase 1, or RNA-editing deaminase 1, or RNA-editing enzyme 1, or dsRNA adensine deaminase, and encoded by the human gene ADARB1/ ADAR2, DRADA2, RED1 is an enzyme that catalyzes the deamination of adenosine in dsRNA to inosine in a step called A to I RNA editing. This editing alters gene expression by changing codon usage and splicing sites as well as altering general RNA stability. So far the enzyme has been shown to edit and destabilize cancer associated genes as well as functional neurotransmitter receptors, and channel proteins. Interestingly, its activity appears to inhibit cell proliferation and migration in some cells and promote exocytosis and metabolism in others, likely to do differential affects on particular important mRNAs. Highly expressed in brain, heart with lower expression in lung, kidney and liver tissues. Interestingly RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ADAR2 Antibody, clone 1.3.1 detects level of ADAR2 & has been published & validated for use in ADAR2.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human ADAR2.
      EpitopeC-terminus
      Clone1.3.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ADARB1
      • ADAR2
      • DRADA2
      • RED1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~80 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected ADAR2 in 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE889 04053252946875