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171375 Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem

A polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fungizone

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1397-89-3C₄₇H₇₃NO₁₇
      Description
      OverviewA polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.
      Catalogue Number171375
      Brand Family Calbiochem®
      SynonymsFungizone
      References
      ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
      Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
      Barth, C., et al. 1993. J. Biophys. 64, 92.
      Product Information
      CAS number1397-89-3
      FormYellow solid
      Hill FormulaC₄₇H₇₃NO₁₇
      Chemical formulaC₄₇H₇₃NO₁₇
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>86% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBU2625000
      Safety Information
      R PhraseR: 20/21-36/37/38

      Harmful by inhalation and in contact with skin.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      171375 0

      Documentation

      Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      171375

      References

      Reference overview
      Tollemar, J., et al. 1995. Transplantation 59, 45.
      Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
      Barth, C., et al. 1993. J. Biophys. 64, 92.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-July-2007 RFH
      SynonymsFungizone
      DescriptionAn antifungal agent. A polyene antibiotic that nonspecifically induces the loss of low molecular weight substances from cells. Causes suppression of bone marrow progenitor cells. Probably forms channels by complexing with membrane cholesterol. Effective against fungi and yeast at concentrations of 1-10 µg/ml.
      FormYellow solid
      CAS number1397-89-3
      RTECSBU2625000
      Chemical formulaC₄₇H₇₃NO₁₇
      Structure formulaStructure formula
      Purity>86% by HPLC
      SolubilityDMF or DMSO (30-40 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
      Toxicity Harmful
      Merck USA index14, 585
      ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
      Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
      Barth, C., et al. 1993. J. Biophys. 64, 92.