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124019 Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem

The Akt Inhibitor IX, API-59CJ-OMe, also referenced under CAS 98510-80-6, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphory

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Synonyms: MMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505

Primary Target: Akt
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      98510-80-6C₂₁H₂₂N₂O₃ • 3H₂O
      Description
      OverviewA cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
      Catalogue Number124019
      Brand Family Calbiochem®
      SynonymsMMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
      References
      ReferencesJin, X., et al. 2004. Br. J. Cancer 91, 1808.
      Product Information
      CAS number98510-80-6
      ATP CompetitiveN
      FormOrange red solid
      Hill FormulaC₂₁H₂₂N₂O₃ • 3H₂O
      Chemical formulaC₂₁H₂₂N₂O₃ • 3H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>12-24 µM against Akt
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      124019 0