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121800 Advanced Glycation Endproduct-BSA

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121800
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121800-10MG
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      Description
      OverviewPrepared by reacting BSA with glycoaldehyde under sterile conditions. Glycated-BSA shows a 5,000 - 10,000% increase in fluorescence as compared to normal BSA (confirmed by fluorescence spectrophotometry, excitation/emission 370/440 nm). AGE-BSA has been reported to induce apoptosis in cultured human umbilical vein endothelial cells and inhibit nitric oxide synthase activity in proximal tubular epithelial cells. Advanced glycation end products and their receptors have been implicated in the pathogenesis of diabetes, induction of proinflammatory cytokines, and stimulation of smooth muscle proliferation, and fibronectin production.
      Catalogue Number121800
      Brand Family Calbiochem®
      SynonymsAGE-BSA
      References
      ReferencesOkamoto, T., et al. 2002. Microvasc. Res. 63, 186.
      Ohgami, N., et al. 2001. J. Biol. Chem. 276, 3195.
      Wang, R., et al. 2001. J. Nippon Med. Sch. 68, 472.
      Sakata, N., et al. 2000. J. Atheroscler. Thromb. 7, 169.
      Verbeke, P., et al. 2000. Biochim. Biophys. Acta 1502, 481.
      Farboud, B., et al. 1999. Mol. Vis. 5, 11.
      Huang, J.-S., et al. 1999. Biochem. J. 342, 231.
      Min, C., et al. 1999. Diabetes Res. Clin. Pract. 46, 197.
      Neumann, A., et al. 1999. FEBS Lett. 453, 283.
      Stitt, A.W., et al. 1999. Biochem. Biophys. Res. Commun. 256, 549.
      Nazaimoon, W. and Bak, K. 1998. Malays. J. Pathol. 20, 83.
      Product Information
      FormLiquid
      FormulationIn sterile-filtered PBS.
      Quality LevelMQ100
      Biological Information
      Purity≥95% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Global Trade Item Number
      Catalogue Number GTIN
      121800-10MG 04055977206197