Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
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-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
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Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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119136
Sigma-AldrichAdenosine A1 Receptor Agonist II, CCPA - CAS 37739-05-2 - Calbiochem
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Description
Overview
An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.
Adenosine A1 Receptor Agonist II, CCPA - CAS 37739-05-2 - Calbiochem Certificates of Analysis
Title
Lot Number
119136
References
Reference overview
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1. Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382. Mironov, S., et al. 1990. J Neurophysiol.81, 1. Monopoli, A., et al. 1994.Arzneimittelforschung.44, 1305. Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844. Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687. Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
37739-05-2
Chemical formula
C₁₅H₂₀ClN₅O₄
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (100 mM) or H₂O (5 mM)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1. Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382. Mironov, S., et al. 1990. J Neurophysiol.81, 1. Monopoli, A., et al. 1994.Arzneimittelforschung.44, 1305. Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844. Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687. Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.
