118500 Sigma-AldrichATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM).
More>> ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 587871-26-9 | C₂₁H₁₇NO₃S₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 118500-10MG |
|
Glass bottle | 10 mg |
|
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| 118500-2MG |
|
Glass bottle | 2 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available. |
| Catalogue Number | 118500 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933 |
| References | |
|---|---|
| References | Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056. Lau, A., et al. 2005. Nat. Cell Biol. 7, 493. Hickson, I., et al. 2004. Cancer Res. 64, 9152. |
| Product Information | |
|---|---|
| CAS number | 587871-26-9 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₂₁H₁₇NO₃S₂ |
| Chemical formula | C₂₁H₁₇NO₃S₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | ATM Kinase |
| Primary Target IC<sub>50</sub> | 13 nM |
| Primary Target K<sub>i</sub> | 2.2 nM for ATM kinase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 118500-10MG | 04055977224030 |
| 118500-2MG | 07790788047894 |