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171258 AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem

A cell-permeable, direct, potent, selective, reversible, and allosteric activator of AMPK (EC₅₀ = 0.8 µM for rat liver).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

171258
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
844499-71-4C₂₀H₁₂N₂O₃S

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171258-5MG
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      Description
      OverviewA cell-permeable thienopyridone compound that acts as a direct, potent, selective, reversible, and allosteric activator of AMPK (EC50 = 0.8 µM, 1.9 µM and 2.2 µM in partially purified AMPK from rat liver, muscle and heart, respectively; 0.7 µM for AMPKα1,β1,γ1 isoform and 1.1 µM in HEK cells). Acts by inhibiting the dephosphorylation of AMPKT172. Does neither affect GPPase and FBPase activities at 100 µM, and a panel of 67-receptors and ion-channels at 10 µM nor alter the intracellular levels of ATP and AMP. Specifically stimulates hepatic AMPK in ob/ob mouse model (30 mg/kg, i.p.), improves insulin-sensitivity and regulates glucose and lipid metabolism. Shown to reduce mRNA expression levels of several gluconeogenic enzymes.
      Catalogue Number171258
      Brand Family Calbiochem®
      Synonyms6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
      References
      ReferencesSanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
      Cool, B., et al. 2006. Cell Metab. 3, 403.
      Product Information
      CAS number844499-71-4
      FormOff-white solid
      Hill FormulaC₂₀H₁₂N₂O₃S
      Chemical formulaC₂₀H₁₂N₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsSoluble in DMSO (mg/ml), EtOH (mg/ml); aliquot and store at -20*C; stable for 6 months.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      171258-5MG 04053252040863

      Documentation

      AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      171258

      References

      Reference overview
      Sanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
      Cool, B., et al. 2006. Cell Metab. 3, 403.