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220467 2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2CdA, Cladribine

Primary Target: Antileukemic and immunosuppressive activity
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220467
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4291-63-8C₁₀H₁₂ClN₅O₃

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      Description
      OverviewA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
      Catalogue Number220467
      Brand Family Calbiochem®
      Synonyms2CdA, Cladribine
      References
      ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
      Robertson, L.E., et al. 1993. Blood 81, 143.
      Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
      Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
      Product Information
      CAS number4291-63-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₂ClN₅O₃
      Chemical formulaC₁₀H₁₂ClN₅O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAntileukemic and immunosuppressive activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAU7357560
      Safety Information
      R PhraseR: 20/21/22-36/37/38-40

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-24/25-26-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      220467-10MG 04055977201116

      Documentation

      2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      220467

      References

      Reference overview
      Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
      Robertson, L.E., et al. 1993. Blood 81, 143.
      Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
      Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      Synonyms2CdA, Cladribine
      DescriptionA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
      FormWhite solid
      CAS number4291-63-8
      RTECSAU7357560
      Chemical formulaC₁₀H₁₂ClN₅O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2337
      ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
      Robertson, L.E., et al. 1993. Blood 81, 143.
      Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
      Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.