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565764 γ-Secretase Substrate, Fluorogenic - Calbiochem

An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NMA-GGVVIATVK(DNP)-DRDRDR-NH₂

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565764
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565764-1MG
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      Description
      OverviewAn internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase. Shown to be sensitive and useful for assaying γ-secretase activity. The proteolysis at the Aβ40-, Aβ42-, and Aβ43-generating cleavage sites results in enhanced fluorescence.
      Catalogue Number565764
      Brand Family Calbiochem®
      SynonymsNMA-GGVVIATVK(DNP)-DRDRDR-NH₂
      References
      ReferencesFarmery, M.R., et al. 2003. J. Biol. Chem. 278, 24277.
      Product Information
      ATP CompetitiveN
      FormYellow Lyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₀H₁₁₆N₂₆O₁₈
      Chemical formulaC₇₀H₁₁₆N₂₆O₁₈
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary Targetγ-secretase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceNMA-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(DNP)-D-Arg-D-Arg-D-Arg-NH₂
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with a stream of inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      565764-1MG 04055977267730