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565749 β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

Primary Target: β-secretase
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565749
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
263563-09-3C₂₅H₃₉N₃O₅

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      565749-5MG
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          Description
          OverviewA potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
          Catalogue Number565749
          Brand Family Calbiochem®
          SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
          References
          ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
          Product Information
          CAS number263563-09-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₅H₃₉N₃O₅
          Chemical formulaC₂₅H₃₉N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetβ-secretase
          Primary Target IC<sub>50</sub>700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Val-Leu-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          565749-1MG 04055977267655
          565749-5MG 04055977267662

          Documentation

          β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          565749

          References

          Reference overview
          Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
          DescriptionA potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number263563-09-3
          Chemical formulaC₂₅H₃₉N₃O₅
          Peptide SequenceZ-Val-Leu-Leu-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.