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475878 (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca2+ flux.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I

Primary Target: NMDA receptor
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      77086-22-7C₁₆H₁₅N · C₄H₄O₄
      Description
      OverviewA highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
      Catalogue Number475878
      Brand Family Calbiochem®
      Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
      References
      ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
      DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
      Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.
      Product Information
      CAS number77086-22-7
      FormWhite solid
      Hill FormulaC₁₆H₁₅N · C₄H₄O₄
      Chemical formulaC₁₆H₁₅N · C₄H₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptor
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475878 0

      Documentation

      (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      475878

      References

      Reference overview
      Ikonomidou, C., et al. 1999. Science 283, 70.
      DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
      Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

      Brochure

      Title
      Excitotoxic Glutamate Analogs Technical Bulletin
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-January-2010 JSW
      Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
      DescriptionA highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
      FormWhite solid
      CAS number77086-22-7
      Chemical formulaC₁₆H₁₅N · C₄H₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol or H₂O (3 mg/ml). Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 3386
      ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
      DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
      Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.