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407721 m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem

A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties.

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Synonyme: 3-Iodobenzylguanidine, Hemisulfate, MIBG

Primary Target: Arginine-dependent mono-ADP-ribosylation
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      80663-95-2C₈H₁₀IN₃ • 1/2H₂SO₄
      Description
      Overview

      This product has been discontinued.



      A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI3-kinases.
      Catalogue Number407721
      Brand Family Calbiochem®
      Synonyms3-Iodobenzylguanidine, Hemisulfate, MIBG
      References
      ReferencesYau, L., et al. 2004. Exp. Cell Res. 301, 320.
      Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
      Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
      Smets, L., et al. 1988. Leuk. Res. 12, 737.
      Product Information
      CAS number80663-95-2
      ATP CompetitiveY
      FormColorless to white solid
      Hill FormulaC₈H₁₀IN₃ • 1/2H₂SO₄
      Chemical formulaC₈H₁₀IN₃ • 1/2H₂SO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetArginine-dependent mono-ADP-ribosylation
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      407721 0

      Documentation

      m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      407721

      Literatur

      Übersicht
      Yau, L., et al. 2004. Exp. Cell Res. 301, 320.
      Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
      Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
      Smets, L., et al. 1988. Leuk. Res. 12, 737.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2008 RFH
      Synonyms3-Iodobenzylguanidine, Hemisulfate, MIBG
      DescriptionA cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI-3 kinases.
      FormColorless to white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number80663-95-2
      Chemical formulaC₈H₁₀IN₃ • 1/2H₂SO₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesYau, L., et al. 2004. Exp. Cell Res. 301, 320.
      Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
      Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
      Smets, L., et al. 1988. Leuk. Res. 12, 737.