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344038 cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem

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Synonyme: 4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      959861-21-3C₂₅H₂₃N₃O₃S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
      Catalogue Number344038
      Brand Family Calbiochem®
      Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
      References
      ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
      Product Information
      CAS number959861-21-3
      FormYellow solid
      Hill FormulaC₂₅H₂₃N₃O₃S
      Chemical formulaC₂₅H₂₃N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      344038 0

      Documentation

      cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      344038

      Literatur

      Übersicht
      Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
      DescriptionA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number959861-21-3
      Chemical formulaC₂₅H₂₃N₃O₃S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.