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684500 Zaprinast - CAS 37762-06-4 - Calbiochem

Zaprinast - CAS 37762-06-4 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948

Primary Target: cGMP-specific phosphodiesterase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      37762-06-4C₁₃H₁₃N₅O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 450 nM). Inhibits PDE IX at higher concentration (IC50 = 35 µM). Also known to increase cGMP levels in spontaneously hypertensive rat (SHR) plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
      Catalogue Number684500
      Brand Family Calbiochem®
      Synonyms1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
      References
      ReferencesFisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
      Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
      Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
      Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
      Burns, F., et al. 1992. Biochem. J. 283, 487.
      Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.
      Product Information
      CAS number37762-06-4
      ATP CompetitiveN
      FormTan to pink solid
      Hill FormulaC₁₃H₁₃N₅O₂
      Chemical formulaC₁₃H₁₃N₅O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetcGMP-specific phosphodiesterase
      Primary Target IC<sub>50</sub>450 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      684500 0

      Documentation

      Zaprinast - CAS 37762-06-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      684500

      Literatur

      Übersicht
      Fisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
      Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
      Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
      Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
      Burns, F., et al. 1992. Biochem. J. 283, 487.
      Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.

      Literaturstellen

      Titel
    • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2017 JSW
      Synonyms1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
      DescriptionSelective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 450 nM). Also known to increase cGMP levels in SHR plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
      FormTan to pink solid
      CAS number37762-06-4
      Chemical formulaC₁₃H₁₃N₅O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml) or ethanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Irritant
      ReferencesFisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
      Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
      Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
      Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
      Burns, F., et al. 1992. Biochem. J. 283, 487.
      Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.
      Citation
    • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
      		•