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508146 WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem

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Synonyme: 5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635

Primary Target: 5-HT1A
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508146
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
634908-75-1C₂₅H₃₄N₄O₂·C₄H₄O₄

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      Description
      OverviewA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
      Catalogue Number508146
      Brand Family Calbiochem®
      Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
      References
      ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
      Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
      Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
      Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
      Product Information
      CAS number634908-75-1
      FormOff-white solid
      Hill FormulaC₂₅H₃₄N₄O₂·C₄H₄O₄
      Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT1A
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.08146.0001 04055977242843

      Documentation

      WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Hunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
      Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
      Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
      Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
      DescriptionA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
      FormOff-white solid
      CAS number634908-75-1
      Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (50 mM). Warming is required for complete solubilization.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
      Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
      Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
      Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.