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679101 Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

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Synonyme: 1,25-(OH)₂-D₃, Calcitriol

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679101
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
32222-06-3C₂₇H₄₄O₃

Preis & Verfügbarkeit

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      Description
      OverviewHas immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
      Catalogue Number679101
      Brand Family Calbiochem®
      Synonyms1,25-(OH)₂-D₃, Calcitriol
      References
      ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
      Product Information
      CAS number32222-06-3
      FormSolid
      Hill FormulaC₂₇H₄₄O₃
      Chemical formulaC₂₇H₄₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSFZ4645000
      Safety Information
      R PhraseR: 26/27/28-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of harm to the unborn child.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      679101-50UG 07790788052348

      Documentation

      Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      679101

      Literatur

      Übersicht
      Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-August-2021 JSW
      Synonyms1,25-(OH)₂-D₃, Calcitriol
      DescriptionActive hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number32222-06-3
      RTECSFZ4645000
      Chemical formulaC₂₇H₄₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 1644
      ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.