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676480 VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem

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Synonyme: (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII

Primary Target: (RTK) inhibitor
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      15966-93-5C₁₈H₁₈N₂O₃
      Description
      Overview

      This product has been discontinued.



      A highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 µM).
      Catalogue Number676480
      Brand Family Calbiochem®
      Synonyms(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII
      References
      ReferencesSun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Product Information
      CAS number15966-93-5
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₈H₁₈N₂O₃
      Chemical formulaC₁₈H₁₈N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target(RTK) inhibitor
      Primary Target IC<sub>50</sub>70 nM against receptor tyrosine kinase (RTK)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      676480 0

      Documentation

      VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      676480

      Literatur

      Übersicht
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      Synonyms(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII
      DescriptionA highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nm) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. It does not inhibit PDGFR, EGFR, and IGF-1 tyrosine kinase activities (IC50 >100 µm).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number15966-93-5
      Chemical formulaC₁₈H₁₈N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSun, L., et al. 1998. J. Med. Chem. 41, 2588.