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676501 VEGFR Tyrosine Kinase Inhibitor V - Calbiochem

The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₅H₂₂N₂O₄ • HCl • H₂O
      Description
      OverviewA cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.
      Catalogue Number676501
      Brand Family Calbiochem®
      SynonymsN-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI
      References
      ReferencesHarmange, J.C., et al. 2008. J. Med. Chem. 51, 1649.
      Weiss, M.M., et al. 2008. J. Med. Chem. 51, 1668.
      Product Information
      FormBeige solid
      Hill FormulaC₂₅H₂₂N₂O₄ • HCl • H₂O
      Chemical formulaC₂₅H₂₂N₂O₄ • HCl • H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      676501 0

      Documentation

      VEGFR Tyrosine Kinase Inhibitor V - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      VEGFR Tyrosine Kinase Inhibitor V - Calbiochem Analysenzertifikate

      TitelChargennummer
      676501

      Literatur

      Übersicht
      Harmange, J.C., et al. 2008. J. Med. Chem. 51, 1649.
      Weiss, M.M., et al. 2008. J. Med. Chem. 51, 1668.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-March-2009 RFH
      SynonymsN-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI
      DescriptionA cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₂₂N₂O₄ • HCl • H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (0.5 mg/ml) or Ethanol (0.2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHarmange, J.C., et al. 2008. J. Med. Chem. 51, 1649.
      Weiss, M.M., et al. 2008. J. Med. Chem. 51, 1668.