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505017 UBP310 - CAS 902464-46-4 - Calbiochem

UBP310 - CAS 902464-46-4 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310

Primary Target: GluK1
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      902464-46-4C₁₄H₁₅N₃O₆S
      Description
      OverviewA potent antagonist highly selective for GluK1 (Kb = 10 nM), GluK3 (IC50 = 23 nM), and GluK1/K5 (Kb = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (Kd = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.
      Catalogue Number505017
      Brand Family Calbiochem®
      SynonymsGluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
      References
      ReferencesPinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
      Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
      Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
      Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
      Mayer, L., et al. 2006. J. Neurosci. 26, 2852.
      Product Information
      CAS number902464-46-4
      FormWhite solid
      Hill FormulaC₁₄H₁₅N₃O₆S
      Chemical formulaC₁₄H₁₅N₃O₆S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGluK1
      Primary Target K<sub>i</sub>10nM
      Secondary targetGluk3
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      505017 0

      Documentation

      UBP310 - CAS 902464-46-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Pinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
      Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
      Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
      Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
      Mayer, L., et al. 2006. J. Neurosci. 26, 2852.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      SynonymsGluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
      DescriptionA potent antagonist highly selective for GluK1 (Kb = 10 nM), GluK3 (IC50 = 23 nM), and GluK1/K5 (Kb = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (Kd = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.
      FormWhite solid
      CAS number902464-46-4
      Chemical formulaC₁₄H₁₅N₃O₆S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
      Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
      Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
      Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
      Mayer, L., et al. 2006. J. Neurosci. 26, 2852.