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657021 Tyrosine Kinase Inhibitor Set II - Calbiochem

The Tyrosine Kinase Inhibitor Set II controls the biological activity of Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Primary Target: EGFR
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      Übersicht

      Replacement Information
      Description
      OverviewContains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.
      Catalogue Number657021
      Brand Family Calbiochem®
      Application Data
      References
      ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
      Meydan, N., et al. 1996. Nature 379, 645.
      Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Product Information
      ATP CompetitiveY
      FormSolid
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Secondary targetPKC, Src family of protein tyrosine kinases, JAK2
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      657021 0

      Documentation

      Tyrosine Kinase Inhibitor Set II - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Tyrosine Kinase Inhibitor Set II - Calbiochem Analysenzertifikate

      TitelChargennummer
      657021

      Literatur

      Übersicht
      Hanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
      Meydan, N., et al. 1996. Nature 379, 645.
      Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

      Broschüre

      Titel
      Protein Kinase Assay and Detection Kits Brochure
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      Application Data
      DescriptionProtein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.

      The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.

      The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      SolubilityConcentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
      Meydan, N., et al. 1996. Nature 379, 645.
      Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.