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648485 TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

Übersicht

Key Spec Table

CAS #Empirical Formula
349085-38-7C₁₈H₂₁N₅O₃

Preis & Verfügbarkeit

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648485-10MG
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      Glasflasche 10 mg
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      Description
      OverviewA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
      Catalogue Number648485
      Brand Family Calbiochem®
      SynonymsHC-030031
      References
      ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
      Product Information
      CAS number349085-38-7
      FormWhite solid
      Hill FormulaC₁₈H₂₁N₅O₃
      Chemical formulaC₁₈H₂₁N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      648485-10MG 04055977185058