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616467 Transglutaminase 2 Inhibitor, ZDON - Calbiochem

Übersicht

Key Spec Table

Empirical Formula
C₃₁H₄₅N₇O₉

Preis & Verfügbarkeit

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616467-5MG
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      Glasflasche 5 mg
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      Description
      OverviewA cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
      Catalogue Number616467
      Brand Family Calbiochem®
      SynonymsZ-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
      References
      ReferencesMcConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
      Product Information
      FormOff-white powder
      Hill FormulaC₃₁H₄₅N₇O₉
      Chemical formulaC₃₁H₄₅N₇O₉
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      616467-5MG 04055977185973