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616404 Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem

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Synonyme: 4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1186649-59-1C₂₂H₂₄N₆ • H₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
      Catalogue Number616404
      Brand Family Calbiochem®
      Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
      References
      ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
      Product Information
      CAS number1186649-59-1
      FormPale yellow solid
      Hill FormulaC₂₂H₂₄N₆ • H₂O
      Chemical formulaC₂₂H₂₄N₆ • H₂O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      616404 0

      Documentation

      Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      616404

      Literatur

      Übersicht
      Kaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
      DescriptionA cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1186649-59-1
      Chemical formulaC₂₂H₂₄N₆ • H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.